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The Mind-Gut Connection
What It’s About
The 100 trillion microbes in your gut shape your mood, decisions, and long-term health. UCLA gastroenterologist Emeran Mayer pulls together decades of research on the gut-brain axis and shows how nutrition, stress, and the microbiome talk to each other constantly. Practical, scientific, and the book that made the microbiome mainstream.
Three Key Ideas
The Gut as a Second Brain
The enteric nervous system contains up to 100 million nerve cells and can run digestion independently, making the gut far more than a passive food tube.
Microbiome and Mood
The 100 trillion microbes in your gut produce serotonin, dopamine, and other signaling molecules that directly shape your emotional state and mental health.
Diet as Information for Your Body
Every meal delivers instructions your gut reads through taste receptors, immune cells, and microbes, and processed food systematically breaks this communication.
Read a Sample
The Mind-Gut Connection How the Hidden Conversation Within Our Bodies Impacts Our Mood, Our Choices, and Our Overall Health Emeran Mayer, 2016
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A twenty-five-year-old who could not stop vomiting
Bill walked into Emeran Mayer's UCLA office with his mother. He was twenty-five, otherwise healthy, and desperate. For eight years he had been cycling through emergency rooms several times a week, doubled over with stomach pain and unstoppable vomiting. He had dropped out of college. He had moved back in with his parents. ER doctors handed him narcotics and labeled him a drug-seeker. Specialists ran endoscopies, CT scans, brain scans. Everything came back normal. Nothing made the symptoms stop.
His mother, a businesswoman with no medical training, had typed his symptoms into Google. "I think he has all the symptoms of cyclical vomiting syndrome," she told Mayer.
Who It’s For
- Anyone who suffers from IBS, chronic gut pain, or unexplained digestive symptoms their doctors cannot explain.
- Anyone who wants to understand the biological link between chronic stress, poor diet, and low-grade depression.
- Anyone curious about how the microbiome shapes mood, appetite, and long-term brain health.
- Anyone looking to make concrete dietary changes backed by clinical research rather than wellness marketing.
About the Author: Emeran Mayer
Emeran Mayer is a German-trained gastroenterologist who has spent over forty years at UCLA studying the communication between the brain and the digestive system. He is the executive director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience and a co-founder of the UCLA Microbiome Center.
Mayer has personally treated thousands of patients with IBS, cyclical vomiting syndrome, and chronic gut pain, and his research is funded by the NIH and published in peer-reviewed journals. He writes from clinical experience rather than from theory, grounding every chapter in real patients and primary literature.
